Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	2256
interventional	1801
Observational	420
Registry	35

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	774
Behavioral	165
Other	141
Procedure	122
Biological\|Drug	92
Drug\|placebo	79
Biological	61
Device	59
Drug\|Procedure	39
Drug\|Other	22
Dietary Supplement	19
Behavioral\|Other	18
Biological\|Drug\|Other	14
Diagnostic Test	14
Drug\|Radiation	13
Other\|Procedure	12
Device\|Drug	10
Biological\|Procedure	9
Dietary Supplement\|placebo	9
Device\|Drug\|Procedure	8
Dietary Supplement\|Drug	7
Drug\|Procedure\|Radiation	7
Radiation	7
Drug\|Other\|placebo	6
Procedure\|Radiation	6
Biological\|placebo	5
Device\|Other	5
Genetic	5
Combination Product	4
Behavioral\|Procedure	3
Biological\|Drug\|Genetic\|Other	3
Biological\|Drug\|placebo	3
Biological\|Other	3
Biological\|Radiation	3
Combination Product\|Drug	3
Dietary Supplement\|Other	3
Behavioral\|Device	2
Behavioral\|Other\|Procedure	2
Biological\|Drug\|Genetic\|Other\|Procedure	2
Biological\|Drug\|Other\|placebo	2
Device\|Procedure	2
Dietary Supplement\|Drug\|placebo	2
Drug\|Genetic	2
Drug\|Other\|Procedure	2
Drug\|Other\|Procedure\|Radiation	2
Drug\|Other\|Radiation	2
Behavioral\|Device\|Other	1
Behavioral\|Dietary Supplement	1
Behavioral\|Drug	1
Behavioral\|Drug\|placebo	1
Behavioral\|Genetic\|Other	1
Behavioral\|placebo	1
Biological\|Drug\|Genetic	1
Biological\|Drug\|Other\|Procedure\|Radiation	1
Biological\|Drug\|Procedure	1
Biological\|Other\|placebo	1
Biological\|Other\|Procedure	1
Biological\|placebo\|Procedure	1
Biological\|Procedure\|Radiation	1
Combination Product\|Other\|Procedure	1
Device\|Radiation	1
Diagnostic Test\|Drug	1
Diagnostic Test\|Drug\|Procedure	1
Diagnostic Test\|Other	1
Dietary Supplement\|Drug\|Other	1
Dietary Supplement\|Genetic\|Other	1
Dietary Supplement\|Genetic\|Other\|Procedure	1
Dietary Supplement\|Other\|Procedure	1
Dietary Supplement\|Other\|Procedure\|Radiation	1
Drug\|Genetic\|Other\|Procedure	1
Drug\|placebo\|Procedure	1
Other\|placebo	1
Other\|Procedure\|Radiation	1
Other\|Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	611
China	118
NA	114
France	109
Spain	59
Canada	57
United Kingdom	50
Italy	49
Korea, Republic of	49
Germany	41
Japan	36
Denmark	35
Netherlands	35
United States\|Canada	32
Norway	19
Belgium	14
Taiwan	13
Hong Kong	12
Greece	11
Brazil	10
Israel	10
Australia	9
Sweden	9
Switzerland	9
United States\|Puerto Rico	8
Poland	7
Singapore	7
Egypt	6
Austria	5
Argentina	4
Ireland	4
Turkey	4
Belgium\|Germany	3
Belgium\|Spain	3
Czechia	3
Denmark\|Norway\|Sweden	3
Finland	3
Romania	3
United States\|Australia	3
United States\|Germany	3
Australia\|New Zealand	2
Bulgaria	2
Czech Republic	2
Denmark\|Sweden	2
Germany\|Switzerland	2
India	2
Iran, Islamic Republic of	2
Russian Federation	2
Thailand	2
United States\|Italy	2
United States\|Netherlands	2
United States\|United Kingdom	2
Argentina\|Australia\|Austria\|Belgium\|Brazil\|France\|Germany\|Greece\|Hong Kong\|Israel\|Italy\|Mexico\|Poland\|Thailand	1
Argentina\|Australia\|Austria\|Brazil\|Bulgaria\|Czechia\|Denmark\|Estonia\|France\|Germany\|Hungary\|Ireland\|Italy\|Latvia\|Lithuania\|Netherlands\|Poland\|Portugal\|Romania\|Russian Federation\|Slovakia\|Spain\|Sweden\|Ukraine\|United Kingdom	1
Argentina\|Brazil\|India\|Spain\|Ukraine	1
Australia\|Austria\|Brazil\|United States\|Canada\|China\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Guatemala\|Hong Kong\|Hungary\|Ireland\|Israel\|Italy\|Korea, Republic of\|Mexico\|New Zealand\|Norway\|Panama\|Portugal\|Puerto Rico\|Russian Federation\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Thailand\|Turkey\|United Kingdom	1
Australia\|Belgium\|Brazil\|Bulgaria\|Croatia\|France\|Ireland\|Italy\|Panama\|Poland\|Portugal\|Romania\|Slovakia\|Slovenia\|Turkey\|Ukraine	1
Australia\|Belgium\|Brazil\|Denmark\|France\|Germany\|Italy\|Netherlands\|Poland\|Russian Federation\|Spain\|United Kingdom	1
Australia\|Canada	1
Australia\|Canada\|Israel\|Italy\|Korea, Republic of\|Netherlands\|Singapore\|Spain	1
Australia\|Canada\|Japan	1
Australia\|Canada\|New Zealand	1
Australia\|China\|India\|Indonesia\|Korea, Republic of\|Malaysia\|New Zealand\|Philippines\|Saudi Arabia\|Singapore\|Sri Lanka\|Taiwan	1
Australia\|Germany\|Greece\|Netherlands\|Spain	1
Australia\|Germany\|Italy\|Korea, Republic of\|Russian Federation\|Spain\|United Kingdom	1
Australia\|New Zealand\|United Kingdom	1
Australia\|United States\|Belgium\|France\|Germany\|Italy\|Poland\|Spain\|United Kingdom	1
Austria\|Belgium\|Canada\|Czech Republic\|France\|Germany\|Italy\|Spain\|United Kingdom	1
Austria\|Belgium\|Canada\|France\|Germany\|Greece\|Italy\|Norway\|Portugal	1
Austria\|Belgium\|Egypt\|France\|Germany\|Italy\|Netherlands\|Russian Federation\|South Africa	1
Austria\|Belgium\|Egypt\|France\|Germany\|Italy\|Portugal\|Spain\|Switzerland\|United Kingdom	1
Austria\|Belgium\|Estonia\|France\|Germany\|Italy\|Spain\|United Kingdom	1
Austria\|Belgium\|France\|Germany\|Greece\|Israel\|Italy\|Poland\|Portugal\|Romania\|Russian Federation\|Spain\|Ukraine	1
Austria\|Belgium\|France\|Hungary\|Spain	1
Austria\|Belgium\|Netherlands	1
Austria\|Bosnia and Herzegovina\|Bulgaria\|Croatia\|Cyprus\|Czech Republic\|Hungary\|Israel\|Portugal\|Romania\|Slovakia\|Slovenia\|Turkey	1
Austria\|Bosnia and Herzegovina\|Bulgaria\|Croatia\|Estonia\|Greece\|Hungary\|Israel\|Latvia\|Romania\|Serbia\|Slovakia\|Slovenia	1
Austria\|Bosnia and Herzegovina\|Croatia\|Germany\|India\|Italy\|Latvia\|Poland\|Romania\|Russian Federation\|Serbia\|Sweden\|Ukraine	1
Austria\|Canada\|France	1
Austria\|Canada\|Greece\|Hungary\|Italy\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Slovenia\|Spain\|United Kingdom	1
Austria\|Czech Republic\|France\|Germany\|Russian Federation\|United Kingdom	1
Austria\|France\|Germany\|Hungary\|Italy\|Spain\|United Kingdom	1
Austria\|France\|Germany\|Netherlands\|Sweden\|Switzerland	1
Austria\|France\|Spain\|United Kingdom	1
Austria\|France\|United Kingdom	1
Austria\|Germany	1
Austria\|Germany\|Italy\|Korea, Republic of\|Netherlands\|Spain\|Sweden\|Switzerland\|Thailand	1
Austria\|Switzerland	1
Belgium\|Bulgaria\|Cyprus\|Czech Republic\|Germany\|Greece\|Hungary\|Israel\|Poland\|Russian Federation\|Spain\|United Kingdom	1
Belgium\|Bulgaria\|Germany\|Hungary\|Latvia\|Poland\|Romania\|Serbia\|United Kingdom	1
Belgium\|Canada\|France	1
Belgium\|Czechia	1
Belgium\|Czechia\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Spain\|Taiwan\|United Kingdom	1
Belgium\|Denmark\|France\|Germany\|Hong Kong\|Israel\|Italy\|Korea, Republic of\|Portugal\|South Africa\|Spain\|Sweden\|Switzerland\|Taiwan\|Ukraine\|United Kingdom	1
Belgium\|Egypt\|Germany\|Hungary\|Israel	1
Belgium\|France\|Germany\|Italy\|Poland\|Spain\|United Kingdom	1
Belgium\|France\|Germany\|Italy\|Spain	1
Belgium\|France\|Italy\|Portugal	1
Belgium\|France\|Spain	1
Belgium\|Italy\|Netherlands\|Spain	1
Belgium\|Netherlands	1
Belgium\|United Kingdom	1
Belgium\|United States\|Canada\|France\|Italy\|Poland\|Spain\|United Kingdom	1
Belgium\|United States\|Spain	1
Brazil\|Canada\|Chile\|China\|Croatia\|Estonia\|Greece\|India\|Korea, Republic of\|Latvia\|Lithuania\|Malaysia\|Mexico\|Philippines\|Romania\|Serbia	1
Brazil\|Canada\|Cyprus\|United Kingdom	1
Canada\|Spain	1
Canada\|United States\|Australia\|Belgium\|Brazil\|China\|Finland\|France\|Germany\|Greece\|Hong Kong\|Hungary\|Ireland\|Israel\|Italy\|Korea, Republic of\|Mexico\|New Zealand\|Panama\|Poland\|Portugal\|Russian Federation\|Singapore\|South Africa\|Spain\|Switzerland\|Taiwan\|Thailand\|United Kingdom	1
Chile\|United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Czechia\|Denmark\|France\|Germany\|Hungary\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|Norway\|Poland\|Russian Federation\|Spain\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
China\|Hong Kong\|Japan\|Singapore\|Taiwan	1
China\|Hong Kong\|Korea, Republic of\|Taiwan\|Vietnam	1
China\|Italy\|Serbia\|United Kingdom	1
China\|Japan	1
China\|Korea, Republic of\|Thailand	1
Croatia	1
Cuba	1
Cyprus\|Greece	1
Cyprus\|United Kingdom	1
Czech Republic\|Argentina\|Australia\|Brazil\|Bulgaria\|China\|Germany\|Hungary\|India\|Korea, Republic of\|Philippines\|Poland\|Switzerland\|Taiwan\|United Kingdom	1
Czechia\|France\|Germany\|Italy\|Poland\|Russian Federation\|Spain\|Ukraine\|United Kingdom	1
Czechia\|France\|Israel\|Italy\|Netherlands\|Spain	1
Czechia\|France\|Russian Federation\|Spain\|United Kingdom	1
Czechia\|United States\|Australia\|Belgium\|Bulgaria\|Canada\|China\|France\|Hong Kong\|India\|Israel\|Italy\|Korea, Republic of\|Latvia\|Lithuania\|Malaysia\|Netherlands\|Peru\|Philippines\|Poland\|Romania\|Russian Federation\|Serbia\|Singapore\|Slovakia\|South Africa\|Sweden\|Taiwan\|United Kingdom	1
Denmark\|Germany	1
Denmark\|Greece\|Norway\|Sweden	1
Denmark\|Netherlands	1
Denmark\|United States\|Austria\|Belgium\|Canada\|Germany\|Hungary\|Poland	1
France\|Argentina\|Belgium\|Bosnia and Herzegovina\|Brazil\|Denmark\|Egypt\|Germany\|Greece\|Italy\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Portugal\|Russian Federation\|Serbia\|Slovakia\|Slovenia\|Spain\|Sweden\|Turkey\|United Kingdom	1
France\|Austria\|Belgium\|Czech Republic\|Denmark\|Estonia\|Finland\|Germany\|Netherlands\|Norway\|Portugal\|Saudi Arabia\|Spain\|Sweden\|Switzerland	1
France\|Belgium\|Martinique	1
France\|Germany	1
France\|Germany\|Netherlands	1
France\|Hungary\|Korea, Republic of\|Slovakia\|Spain\|Taiwan	1
France\|Ireland\|Israel	1
France\|United Kingdom	1
France\|United States\|Belgium\|China\|Germany\|Hong Kong\|Italy\|Korea, Republic of\|Netherlands\|Singapore\|Spain\|Taiwan\|United Kingdom	1
Germany\|Argentina\|Australia\|Austria\|Belgium\|Bosnia and Herzegovina\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Cyprus\|Czech Republic\|Hong Kong\|Hungary\|India\|Ireland\|Korea, Republic of\|Mexico\|Norway\|Poland\|Portugal\|Romania\|Russian Federation\|Serbia\|Singapore\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan\|Thailand\|Ukraine\|United Kingdom	1
Germany\|Israel	1
Germany\|Italy\|Netherlands\|Poland\|Spain\|United Kingdom	1
Germany\|United Kingdom	1
Hungary	1
Hungary\|Germany\|United States\|Argentina\|Australia\|Belgium\|Brazil\|Canada\|China\|Czech Republic\|France\|Israel\|Italy\|Japan\|Netherlands\|Portugal\|Spain\|Switzerland\|Turkey	1
India\|United Kingdom	1
Iraq	1
Israel\|France\|Germany\|Greece\|United States\|Belgium\|Canada\|Croatia\|Finland\|Italy\|Korea, Republic of\|Poland\|Puerto Rico\|Serbia\|Slovakia\|Slovenia\|South Africa\|Spain\|Taiwan\|United Kingdom	1
Italy\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Chile\|Czech Republic\|Finland\|France\|Germany\|Greece\|Hong Kong\|Hungary\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Romania\|Russian Federation\|Singapore\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
Italy\|Switzerland\|United Kingdom	1
Jordan	1
Lithuania	1
Malaysia	1
Netherlands\|Switzerland	1
Netherlands\|United Kingdom	1
New Zealand	1
Norway\|Poland	1
Norway\|Sweden	1
Philippines	1
Puerto Rico	1
United Kingdom\|United States\|Belgium\|Germany\|Netherlands\|Spain	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Canada\|Chile\|China\|Czechia\|Denmark\|France\|Germany\|Greece\|Ireland\|Italy\|Japan\|Netherlands\|Norway\|Puerto Rico\|Romania\|Spain\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Chile\|Czech Republic\|Denmark\|Estonia\|France\|Germany\|Greece\|Italy\|Korea, Republic of\|Netherlands\|New Zealand\|Norway\|Poland\|Puerto Rico\|Romania\|Russian Federation\|South Africa\|Spain\|Sweden\|Turkey\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Czechia\|Denmark\|Finland\|France\|Germany\|Greece\|Hungary\|India\|Israel\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Portugal\|Puerto Rico\|Romania\|Slovenia\|Spain\|Sweden\|Taiwan	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Canada\|Czechia\|Denmark\|France\|Germany\|Hong Kong\|Israel\|Italy\|Japan\|Korea, Republic of\|Mexico\|Netherlands\|Poland\|Portugal\|Russian Federation\|Spain\|Sweden\|Taiwan\|Turkey\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Canada\|Chile\|Germany\|Hungary\|Italy\|Poland\|Portugal\|Spain\|United Kingdom	1
United States\|Argentina\|Austria\|Brazil\|Bulgaria\|Canada\|Colombia\|Greece\|Hungary\|Italy\|Mexico\|Peru\|Poland\|Romania\|Russian Federation\|Spain\|Turkey\|Ukraine	1
United States\|Argentina\|Brazil\|Chile\|Peru	1
United States\|Argentina\|Denmark\|Italy\|Korea, Republic of\|Spain\|Sweden	1
United States\|Argentina\|Italy	1
United States\|Argentina\|Korea, Republic of\|Norway\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Brazil\|Canada\|France\|Germany\|Hong Kong\|Italy\|New Zealand\|Portugal\|Slovakia\|Spain\|Sweden\|Switzerland\|Taiwan\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|Chile\|Czechia\|Germany\|Hong Kong\|Israel\|Italy\|Japan\|Korea, Republic of\|Singapore\|Spain\|Taiwan\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Canada\|Czech Republic\|Egypt\|Finland\|France\|Germany\|Hungary\|India\|Israel\|Italy\|Latvia\|Malta\|Philippines\|Poland\|Russian Federation\|Slovakia\|South Africa\|Spain\|Taiwan\|Thailand\|Turkey\|Ukraine\|United Kingdom\|Vietnam	1
United States\|Australia\|Austria\|Belgium\|Canada\|Czech Republic\|Finland\|Hungary\|Italy\|Netherlands\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Czech Republic\|Finland\|France\|Germany\|Hong Kong\|Italy\|Netherlands\|Norway\|Portugal\|Slovakia\|Sweden\|Switzerland\|United Kingdom	1
United States\|Australia\|Austria\|Belgium\|Czechia\|France\|Germany\|Ireland\|Italy\|Japan\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Austria\|Canada\|France\|Germany\|Greece\|Japan\|Spain\|Sweden	1
United States\|Australia\|Belgium\|Brazil\|Canada\|Czech Republic\|Greece\|Korea, Republic of\|New Zealand\|Poland\|Portugal\|Romania\|Russian Federation\|Spain	1
United States\|Australia\|Belgium\|Brazil\|Canada\|Czechia\|France\|Germany\|Hungary\|Italy\|Netherlands\|New Zealand\|Portugal\|Slovakia\|Spain\|Sweden\|Switzerland\|Taiwan\|United Kingdom	1
United States\|Australia\|Belgium\|Bulgaria\|Canada\|Czechia\|France\|Hungary\|Ireland\|Italy\|Latvia\|Mexico\|Poland\|Romania\|Russian Federation\|Slovakia\|Ukraine	1
United States\|Australia\|Belgium\|Canada\|China\|Czechia\|France\|Germany\|Hong Kong\|Israel\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Singapore\|Spain	1
United States\|Australia\|Belgium\|Canada\|France\|Germany\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Norway\|Spain	1
United States\|Australia\|Belgium\|Canada\|France\|Ireland\|Italy\|Spain	1
United States\|Australia\|Belgium\|Canada\|France\|Israel\|Italy\|Netherlands\|Singapore\|Spain	1
United States\|Australia\|Belgium\|Canada\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Germany\|Netherlands\|Spain	1
United States\|Australia\|Belgium\|Canada\|Germany\|Spain	1
United States\|Australia\|Belgium\|China\|France\|Germany\|Hong Kong\|Italy\|Japan\|Korea, Republic of\|Netherlands\|Poland\|Singapore\|Spain\|Taiwan\|United Kingdom	1
United States\|Australia\|Belgium\|France\|Germany\|Israel\|Italy\|Korea, Republic of\|New Zealand\|Portugal\|Singapore\|Spain\|Taiwan	1
United States\|Australia\|Belgium\|France\|Germany\|Israel\|Italy\|New Zealand\|Poland\|Spain\|Switzerland	1
United States\|Australia\|Belgium\|France\|Germany\|Italy\|New Zealand\|Romania\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Germany\|Spain\|Switzerland	1
United States\|Australia\|Belgium\|Poland\|Spain	1
United States\|Australia\|Canada\|France\|Spain	1
United States\|Australia\|Canada\|Israel\|Korea, Republic of	1
United States\|Australia\|Canada\|New Zealand	1
United States\|Australia\|France\|Korea, Republic of\|Spain\|Switzerland\|United Kingdom	1
United States\|Australia\|India\|Russian Federation\|Ukraine	1
United States\|Australia\|Peru\|Puerto Rico	1
United States\|Austria\|Belgium\|Canada\|China\|France\|Germany\|Italy\|Korea, Republic of\|Poland\|Singapore\|Spain\|United Kingdom	1
United States\|Austria\|Belgium\|France\|Germany\|Hungary\|Italy\|Poland\|Russian Federation\|Spain	1
United States\|Austria\|Belgium\|France\|Germany\|Italy\|Japan\|Netherlands\|Spain\|United Kingdom	1
United States\|Austria\|France\|Germany\|Italy\|Puerto Rico	1
United States\|Belgium	1
United States\|Belgium\|Brazil\|Canada\|Chile\|Czechia\|Denmark\|Finland\|Germany\|Spain\|Ireland\|Israel\|Italy\|Lebanon\|Mexico\|Netherlands\|Norway\|Puerto Rico\|Russian Federation\|Sweden\|Thailand\|Turkey\|United Kingdom	1
United States\|Belgium\|Canada\|France\|Italy\|Netherlands\|Spain	1
United States\|Belgium\|Canada\|Germany\|Italy\|Lithuania\|Netherlands\|United Kingdom	1
United States\|Belgium\|Canada\|Germany\|Italy\|Spain	1
United States\|Belgium\|Canada\|Germany\|Netherlands\|Spain\|United Kingdom	1
United States\|Belgium\|Canada\|Korea, Republic of\|Spain\|Taiwan	1
United States\|Belgium\|Czechia\|France\|Germany\|Hong Kong\|Hungary\|Italy\|Japan\|Korea, Republic of\|Spain\|Taiwan\|United Kingdom	1
United States\|Belgium\|France\|Italy\|Japan\|Netherlands\|Spain\|United Kingdom	1
United States\|Belgium\|France\|Spain	1
United States\|Belgium\|France\|Spain\|United Kingdom	1
United States\|Belgium\|Germany\|India\|Spain\|United Kingdom	1
United States\|Belgium\|Hungary\|Italy\|Poland\|Romania\|Russian Federation\|Spain\|Ukraine\|United Kingdom	1
United States\|Belgium\|Italy\|Netherlands\|United Kingdom	1
United States\|Belgium\|Netherlands\|Spain\|United Kingdom	1
United States\|Belgium\|United Kingdom	1
United States\|Brazil\|Canada\|Czech Republic\|Hungary\|Poland\|United Kingdom	1
United States\|Bulgaria\|Denmark\|Georgia\|Germany\|Portugal\|Serbia\|Sweden	1
United States\|Bulgaria\|India\|Peru\|Puerto Rico\|Romania	1
United States\|Canada\|Estonia\|Ireland\|Norway\|Portugal\|Switzerland	1
United States\|Canada\|France	1
United States\|Canada\|France\|Germany\|Israel\|Netherlands\|Poland\|Puerto Rico\|Spain\|Sweden	1
United States\|Canada\|France\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Canada\|France\|Italy\|Japan\|Korea, Republic of\|Poland\|Spain	1
United States\|Canada\|Japan\|Puerto Rico\|Spain	1
United States\|Canada\|Puerto Rico\|South Africa	1
United States\|Canada\|Spain	1
United States\|Czech Republic\|Italy	1
United States\|France	1
United States\|France\|Germany\|Italy\|Russian Federation	1
United States\|France\|Hong Kong\|Hungary\|India\|Italy\|Poland\|Russian Federation\|Singapore\|Spain	1
United States\|Germany\|Hong Kong\|Japan	1
United States\|Germany\|Hungary\|Sweden\|Switzerland	1
United States\|Germany\|Netherlands	1
United States\|Iceland\|Netherlands\|Norway\|Poland\|Sweden	1
United States\|Ireland	1
United States\|Israel	1
United States\|Italy\|Japan\|Spain\|United Kingdom	1
United States\|Italy\|United Kingdom	1
United States\|Japan	1
United States\|Japan\|Spain\|Ukraine	1
United States\|Netherlands\|Spain	1
United States\|Puerto Rico\|South Africa	1
United States\|Russian Federation	1
United States\|Spain	1
United States\|Spain\|United Kingdom	1
Vietnam	1

Sites per Study

Site_count	Study_Count
1	1004
2	146
3	84
4	53
5	40
6	37
7	28
8	32
9	22
10	21
11	15
12	26
13	14
14	14
15	13
16	13
17	9
18	12
19	10
20	6
21	5
22	6
23	5
24	10
25	5
26	3
27	3
28	2
29	6
30	5
31	1
32	5
33	6
34	4
35	2
36	3
37	5
39	3
40	3
41	1
42	2
43	1
44	3
46	3
47	4
48	2
49	3
51	2
52	2
54	1
55	1
56	1
57	5
58	2
60	1
61	1
62	1
63	1
65	3
66	2
67	4
70	1
73	2
74	2
75	1
76	1
77	2
78	2
79	1
82	1
83	2
86	2
87	1
88	1
90	1
91	1
95	1
98	2
99	1
102	1
106	1
107	1
110	1
111	2
115	1
116	1
117	1
127	2
129	1
130	1
140	1
145	1
151	1
152	1
154	3
155	2
160	1
162	1
167	1
171	2
175	1
179	1
188	1
211	1
213	1
221	1
223	1
232	1
235	1
236	1
240	1
251	1
255	1
272	1
283	1
301	1
466	1
683	1
709	1
763	1
963	1
1328	1

Phase

Phase	Study_Count
Phase 2	586
N/A	526
Phase 1	223
Phase 3	211
Phase 1/Phase 2	162
Phase 4	50
Phase 2/Phase 3	31
Early Phase 1	12

Number of Arms

Number_of_Arms	Count_of_Studies
1	544
2	758
3	148
4	76
5	14
6	8
7	4
8	5
9	3
10	1
12	2
14	1
18	1
24	1
37	1
NA	234

Number of Updates

Count of Versions	Count of Studies
1	146
2	199
3	179
4	179
5	151
6	122
7	80
8	66
9	84
10	69
11	71
12	44
13	40
14	30
15	26
16	23
17	26
18	17
19	12
20	13
21	11
22	10
23	8
24	6
25	5
26	14
27	8
28	8
29	5
30	7
31	5
32	9
33	9
34	8
35	4
36	3
37	1
38	4
39	6
40	1
41	6
42	3
43	7
44	3
45	2
46	1
47	3
48	3
49	3
50	1
52	2
55	1
56	1
57	1
58	1
59	2
63	1
66	2
67	2
68	2
69	2
71	1
74	4
75	1
77	1
78	2
80	2
83	2
84	1
85	2
87	1
88	1
89	1
90	1
91	1
92	1
93	3
94	1
95	1
96	1
97	1
98	1
99	1
100	1
101	1
105	1
115	1
124	1
125	1
154	1
182	1
289	1
296	1
683	1
881	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	20246	1655	12.233233
Contacts/Locations	9357	1445	6.475433
Recruitment Status	2648	1447	1.829993
Study Design	2118	1178	1.797963
Arms	1956	867	2.256055
Interventions	1956	867	2.256055
None (earliest Version on record)	1801	1801	1.000000
Eligibility	1626	815	1.995092
Study Identification	1532	778	1.969152
Outcome Measures	1527	823	1.855407
Sponsor/Collaborators	1296	817	1.586291
Study Description	1296	721	1.797503
Oversight	806	640	1.259375
Conditions	786	477	1.647799
References	590	326	1.809816
More Information	381	145	2.627586
Results	214	214	1.000000
IPDSharing	203	181	1.121547
Baseline Characteristics	95	82	1.158537
Reported Adverse Events	79	71	1.112676
Results Submission Events	79	79	1.000000
Participant Flow	67	59	1.135593
Documents	43	41	1.048780

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	25.000	4.000	1.0000	5.00000	2.0000	26.000	20.00	20.00
1st Qu.	97.500	60.000	18.0000	30.00000	35.7500	142.000	233.50	40.00
Median	493.500	201.000	28.0000	49.00000	56.0000	333.000	463.00	77.00
Mean	1577.583	3851.517	44.8972	94.20645	107.0779	1098.645	1503.93	402.36
3rd Qu.	1406.500	622.000	48.0000	93.00000	100.2500	541.000	820.00	200.00
Max.	8140.000	206721.000	350.0000	1549.00000	6452.0000	10838.000	95000.00	10000.00

Trial Group Type

group_type	Group_Count
Experimental	2019
Active Comparator	650
NA	234
No Intervention	188
Placebo Comparator	142
Other	139
Sham Comparator	10

Intervention Model

intervention_model	Study_Count
Parallel Assignment	899
Single Group Assignment	695
NA	105
Crossover Assignment	37
Sequential Assignment	36
Factorial Assignment	29

Primary Purpose

primary_purpose	Study_Count
Treatment	1211
Prevention	155
Screening	120
Diagnostic	101
Supportive Care	84
Health Services Research	55
Other	37
NA	23
Basic Science	12
Device Feasibility	2
Educational/Counseling/Training	1

Observational Studies

Studies by Country

Country	Study_Count
United States	108
China	39
NA	33
France	30
Italy	20
United Kingdom	20
Canada	18
United States\|Canada	11
Belgium	10
Germany	10
Sweden	10
Korea, Republic of	9
Taiwan	9
Netherlands	7
Denmark	6
Hong Kong	6
Austria	4
Hungary	4
Ireland	4
Israel	4
Spain	4
Greece	3
Norway	3
Croatia	2
Egypt	2
Japan	2
Lebanon	2
Nigeria	2
Poland	2
Serbia	2
Slovakia	2
Switzerland	2
Turkey	2
United States\|Germany	2
United States\|Puerto Rico	2
Argentina	1
Argentina\|Austria\|Belgium\|Croatia\|Czechia\|France\|Germany\|Greece\|Hungary\|Ireland\|Italy\|Netherlands\|Portugal\|Slovenia\|Spain\|Sweden\|Switzerland\|United Kingdom	1
Australia	1
Australia\|Canada	1
Austria\|Belgium\|France\|Germany\|Greece\|Italy\|Netherlands\|Poland\|Romania	1
Austria\|Belgium\|Germany	1
Austria\|Belgium\|Germany\|Italy	1
Belgium\|Cyprus\|France\|Germany\|Greece\|Italy\|Poland\|Portugal\|Spain\|Sweden\|Switzerland	1
Belgium\|Czech Republic\|Denmark\|France\|Germany\|Italy\|Netherlands\|Spain\|Sweden	1
Brazil	1
Czechia	1
Finland	1
France\|Germany\|United Kingdom	1
Germany\|Hungary	1
Germany\|Ireland\|Spain	1
Germany\|Serbia\|United Kingdom	1
Ireland\|Germany	1
Italy\|Spain	1
Latvia\|Lithuania	1
Puerto Rico	1
Russian Federation	1
South Africa	1
Spain\|United Kingdom\|Croatia\|Denmark\|Finland\|France\|Germany\|Greece\|Italy\|Portugal	1
Thailand	1

Sites per Study

Site_count	Study_Count
1	286
2	27
3	18
4	6
5	13
6	9
7	3
8	2
9	5
10	3
11	1
12	2
13	2
14	3
15	1
17	2
18	1
19	2
20	1
21	1
22	2
23	2
24	1
26	1
27	1
29	1
31	1
32	2
33	1
39	2
40	1
41	1
43	1
47	1
50	1
59	1
65	1
70	1
72	1
73	1
84	1
100	1
113	1
118	1
126	1
143	1
166	1
185	1

Number of Updates

Count of Versions	Count of Studies
1	80
2	69
3	58
4	38
5	31
6	13
7	14
8	12
9	9
10	11
11	9
12	10
13	5
14	5
15	4
16	3
17	1
18	3
20	1
21	2
22	2
24	1
25	2
26	1
27	2
28	2
30	1
31	2
32	1
33	1
36	1
37	1
41	1
43	1
44	1
45	1
47	1
53	1
54	1
55	2
56	1
57	1
58	1
62	1
64	2
65	1
68	1
69	1
70	1
71	1
75	1
76	1
85	1
92	1
164	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	3452	340	10.152941
Contacts/Locations	1244	271	4.590406
None (earliest Version on record)	420	420	1.000000
Recruitment Status	417	253	1.648221
Study Design	414	233	1.776824
Study Description	278	121	2.297521
Eligibility	252	145	1.737931
Outcome Measures	186	138	1.347826
Sponsor/Collaborators	176	121	1.454546
Groups	175	107	1.635514
Interventions	175	107	1.635514
Study Identification	160	102	1.568628
Conditions	96	60	1.600000
Oversight	93	82	1.134146
References	75	47	1.595745
IPDSharing	29	24	1.208333
Results	18	18	1.000000
More Information	5	5	1.000000
Documents	2	2	1.000000
Results Submission Events	2	2	1.000000
Baseline Characteristics	1	1	1.000000
Reported Adverse Events	1	1	1.000000

Enrollment Metrics

Measure	Observational
Min	1.00
1st Qu	81.00
Median	253.00
Mean	19236.25
3rd Qu	795.75
Max	4710504.00

Observation Model

observational_model	Study_Count
Cohort	236
Case-Only	64
Case-Control	42
Other	25
Case Control	20
NA	17
Ecologic or Community	7
Family-Based	7
Case-Crossover	2

Time Perspective

time_perspective	Study_Count
Prospective	324
Retrospective	50
Cross-Sectional	21
Other	15
NA	10

Registries

Studies by Country

Country	Study_Count
China	4
Italy	4
Spain	4
Denmark	3
Austria	2
France	2
NA	2
Argentina	1
Belgium	1
Czechia	1
Egypt	1
Germany	1
Korea, Republic of	1
Netherlands	1
Norway	1
Romania	1
Sweden	1
Taiwan	1
United Kingdom	1
United States	1
United States\|Canada	1

Sites per Study

Site_count	Study_Count
1	28
2	1
4	1
9	1
15	1
17	1
30	1
56	1

Number of Updates

Count of Versions	Count of Studies
1	12
2	9
3	6
4	1
5	5
8	1
20	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	70	23	3.043478
None (earliest Version on record)	35	35	1.000000
Contacts/Locations	34	15	2.266667
Recruitment Status	19	13	1.461539
Study Design	15	11	1.363636
Study Description	10	9	1.111111
Groups	8	7	1.142857
Interventions	8	7	1.142857
Outcome Measures	6	4	1.500000
References	5	4	1.250000
Study Identification	5	5	1.000000
Eligibility	3	3	1.000000
Conditions	2	2	1.000000
IPDSharing	2	2	1.000000
Results	1	1	1.000000
Sponsor/Collaborators	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	36.000
1st Qu	145.500
Median	500.000
Mean	3030.771
3rd Qu	1500.000
Max	35000.000

Registry Model

observational_model	Study_Count
Cohort	26
Case-Control	3
Case-Only	3
Other	2
Case Control	1

Time Perspective

time_perspective	Study_Count
Prospective	34
Other	1

Follow-up

target_duration	Study_Count
2 Years	5
3 Years	5
6 Months	5
1 Year	3
10 Years	3
12 Months	3
1 Day	2
5 Years	2
1 Month	1
1 Week	1
18 Months	1
3 Weeks	1
30 Days	1
4 Years	1
50 Years	1

intervention_type	Study_Count
Drug	774
Behavioral	165
Other	141
Procedure	122
Biological\|Drug	92
Drug\|placebo	79
Biological	61
Device	59
Drug\|Procedure	39
Drug\|Other	22
Dietary Supplement	19
Behavioral\|Other	18
Biological\|Drug\|Other	14
Diagnostic Test	14
Drug\|Radiation	13
Other\|Procedure	12
Device\|Drug	10
Biological\|Procedure	9
Dietary Supplement\|placebo	9
Device\|Drug\|Procedure	8
Dietary Supplement\|Drug	7
Drug\|Procedure\|Radiation	7
Radiation	7
Drug\|Other\|placebo	6
Procedure\|Radiation	6
Biological\|placebo	5
Device\|Other	5
Genetic	5
Combination Product	4
Behavioral\|Procedure	3
Biological\|Drug\|Genetic\|Other	3
Biological\|Drug\|placebo	3
Biological\|Other	3
Biological\|Radiation	3
Combination Product\|Drug	3
Dietary Supplement\|Other	3
Behavioral\|Device	2
Behavioral\|Other\|Procedure	2
Biological\|Drug\|Genetic\|Other\|Procedure	2
Biological\|Drug\|Other\|placebo	2
Device\|Procedure	2
Dietary Supplement\|Drug\|placebo	2
Drug\|Genetic	2
Drug\|Other\|Procedure	2
Drug\|Other\|Procedure\|Radiation	2
Drug\|Other\|Radiation	2
Behavioral\|Device\|Other	1
Behavioral\|Dietary Supplement	1
Behavioral\|Drug	1
Behavioral\|Drug\|placebo	1
Behavioral\|Genetic\|Other	1
Behavioral\|placebo	1
Biological\|Drug\|Genetic	1
Biological\|Drug\|Other\|Procedure\|Radiation	1
Biological\|Drug\|Procedure	1
Biological\|Other\|placebo	1
Biological\|Other\|Procedure	1
Biological\|placebo\|Procedure	1
Biological\|Procedure\|Radiation	1
Combination Product\|Other\|Procedure	1
Device\|Radiation	1
Diagnostic Test\|Drug	1
Diagnostic Test\|Drug\|Procedure	1
Diagnostic Test\|Other	1
Dietary Supplement\|Drug\|Other	1
Dietary Supplement\|Genetic\|Other	1
Dietary Supplement\|Genetic\|Other\|Procedure	1
Dietary Supplement\|Other\|Procedure	1
Dietary Supplement\|Other\|Procedure\|Radiation	1
Drug\|Genetic\|Other\|Procedure	1
Drug\|placebo\|Procedure	1
Other\|placebo	1
Other\|Procedure\|Radiation	1
Other\|Radiation	1

Count of Versions	Count of Studies
1	146
2	199
3	179
4	179
5	151
6	122
7	80
8	66
9	84
10	69
11	71
12	44
13	40
14	30
15	26
16	23
17	26
18	17
19	12
20	13
21	11
22	10
23	8
24	6
25	5
26	14
27	8
28	8
29	5
30	7
31	5
32	9
33	9
34	8
35	4
36	3
37	1
38	4
39	6
40	1
41	6
42	3
43	7
44	3
45	2
46	1
47	3
48	3
49	3
50	1
52	2
55	1
56	1
57	1
58	1
59	2
63	1
66	2
67	2
68	2
69	2
71	1
74	4
75	1
77	1
78	2
80	2
83	2
84	1
85	2
87	1
88	1
89	1
90	1
91	1
92	1
93	3
94	1
95	1
96	1
97	1
98	1
99	1
100	1
101	1
105	1
115	1
124	1
125	1
154	1
182	1
289	1
296	1
683	1
881	1

Site_count	Study_Count
1	286
2	27
3	18
4	6
5	13
6	9
7	3
8	2
9	5
10	3
11	1
12	2
13	2
14	3
15	1
17	2
18	1
19	2
20	1
21	1
22	2
23	2
24	1
26	1
27	1
29	1
31	1
32	2
33	1
39	2
40	1
41	1
43	1
47	1
50	1
59	1
65	1
70	1
72	1
73	1
84	1
100	1
113	1
118	1
126	1
143	1
166	1
185	1

Count of Versions	Count of Studies
1	80
2	69
3	58
4	38
5	31
6	13
7	14
8	12
9	9
10	11
11	9
12	10
13	5
14	5
15	4
16	3
17	1
18	3
20	1
21	2
22	2
24	1
25	2
26	1
27	2
28	2
30	1
31	2
32	1
33	1
36	1
37	1
41	1
43	1
44	1
45	1
47	1
53	1
54	1
55	2
56	1
57	1
58	1
62	1
64	2
65	1
68	1
69	1
70	1
71	1
75	1
76	1
85	1
92	1
164	1

Count of Versions	Count of Studies
1	146
2	199
3	179
4	179
5	151
6	122
7	80
8	66
9	84
10	69
11	71
12	44
13	40
14	30
15	26
16	23
17	26
18	17
19	12
20	13
21	11
22	10
23	8
24	6
25	5
26	14
27	8
28	8
29	5
30	7
31	5
32	9
33	9
34	8
35	4
36	3
37	1
38	4
39	6
40	1
41	6
42	3
43	7
44	3
45	2
46	1
47	3
48	3
49	3
50	1
52	2
55	1
56	1
57	1
58	1
59	2
63	1
66	2
67	2
68	2
69	2
71	1
74	4
75	1
77	1
78	2
80	2
83	2
84	1
85	2
87	1
88	1
89	1
90	1
91	1
92	1
93	3
94	1
95	1
96	1
97	1
98	1
99	1
100	1
101	1
105	1
115	1
124	1
125	1
154	1
182	1
289	1
296	1
683	1
881	1

Site_count	Study_Count
1	286
2	27
3	18
4	6
5	13
6	9
7	3
8	2
9	5
10	3
11	1
12	2
13	2
14	3
15	1
17	2
18	1
19	2
20	1
21	1
22	2
23	2
24	1
26	1
27	1
29	1
31	1
32	2
33	1
39	2
40	1
41	1
43	1
47	1
50	1
59	1
65	1
70	1
72	1
73	1
84	1
100	1
113	1
118	1
126	1
143	1
166	1
185	1

Count of Versions	Count of Studies
1	80
2	69
3	58
4	38
5	31
6	13
7	14
8	12
9	9
10	11
11	9
12	10
13	5
14	5
15	4
16	3
17	1
18	3
20	1
21	2
22	2
24	1
25	2
26	1
27	2
28	2
30	1
31	2
32	1
33	1
36	1
37	1
41	1
43	1
44	1
45	1
47	1
53	1
54	1
55	2
56	1
57	1
58	1
62	1
64	2
65	1
68	1
69	1
70	1
71	1
75	1
76	1
85	1
92	1
164	1

colorectal neoplasms

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Count of Versions	Count of Studies
1	146
2	199
3	179
4	179
5	151
6	122
7	80
8	66
9	84
10	69
11	71
12	44
13	40
14	30
15	26
16	23
17	26
18	17
19	12
20	13
21	11
22	10
23	8
24	6
25	5
26	14
27	8
28	8
29	5
30	7
31	5
32	9
33	9
34	8
35	4
36	3
37	1
38	4
39	6
40	1
41	6
42	3
43	7
44	3
45	2
46	1
47	3
48	3
49	3
50	1
52	2
55	1
56	1
57	1
58	1
59	2
63	1
66	2
67	2
68	2
69	2
71	1
74	4
75	1
77	1
78	2
80	2
83	2
84	1
85	2
87	1
88	1
89	1
90	1
91	1
92	1
93	3
94	1
95	1
96	1
97	1
98	1
99	1
100	1
101	1
105	1
115	1
124	1
125	1
154	1
182	1
289	1
296	1
683	1
881	1

Site_count	Study_Count
1	286
2	27
3	18
4	6
5	13
6	9
7	3
8	2
9	5
10	3
11	1
12	2
13	2
14	3
15	1
17	2
18	1
19	2
20	1
21	1
22	2
23	2
24	1
26	1
27	1
29	1
31	1
32	2
33	1
39	2
40	1
41	1
43	1
47	1
50	1
59	1
65	1
70	1
72	1
73	1
84	1
100	1
113	1
118	1
126	1
143	1
166	1
185	1

Count of Versions	Count of Studies
1	80
2	69
3	58
4	38
5	31
6	13
7	14
8	12
9	9
10	11
11	9
12	10
13	5
14	5
15	4
16	3
17	1
18	3
20	1
21	2
22	2
24	1
25	2
26	1
27	2
28	2
30	1
31	2
32	1
33	1
36	1
37	1
41	1
43	1
44	1
45	1
47	1
53	1
54	1
55	2
56	1
57	1
58	1
62	1
64	2
65	1
68	1
69	1
70	1
71	1
75	1
76	1
85	1
92	1
164	1